Published: September 2006
161 pages;
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Description
This research study is about drug delivery
systems. It provides readers with relevant information, insights and analysis. This important medical opportunity is assessed in terms of technical and
business areas. The participating companies are mapped to show where they fit in the industry landscape. This study reviews the kinds of drug delivery systems
that are being used by pharma, biotech or medical device companies.
The report discusses the broad range of drug
delivery systems, the technical advances and the applications that drug makers might use. Key advances include orally dissolving tablets and film strips,
needle- and needle-free injection systems, transdermal patches, transmucosal delivery, RNAi, drug-coated stents, PEG, nanotechnology, liposomes, monoclonal
antibodies, gene delivery, and implants, which all contribute to the many ways that drugs or therapies can be delivered. Drug delivery systems are reviewed in
terms of approaches used for delivering drugs targeting major diseases including cardiovascular, cancer, asthma, diabetes, and the central nervous system among
others.
This market study shows that drug delivery
technologies can help drug makers overcome some of their big challenges. The drug industry continues to see the commercial demise of major branded drugs that
reach their patent expiration date. Billions of dollars in revenues are lost to generic drug makers each year. The technology can be used as part of a ‘line
extension’ strategy to extend the commercial life of their profitable products. Drug delivery can help ‘rescue’ drug projects with technical challenges by using
a customized delivery system.
This report discusses the above topics with
interesting and useful findings. The study estimates that the US drug delivery market value might reach nearly $85 billion by 2010. The research includes over
235 key alliances and M&As through 2006. This study uses 29 figures and tables to illustrate the findings or trends. The profiles about companies important to
the expanding drug delivery market include detailed information about their business and technical activities.
This report would benefit people with job
titles including CEO, VPs, Director of Business Development, Research Directors, Entrepreneurs, Venture Capitalists, Investment Planners, Research Scientists,
Consultants or Industry Analysts.
Table of Contents
1.Introduction
About This Report
Overview
Drug Delivery Systems: Some Definitions
Drug Delivery Systems: What They Can Do
Highlights of Pharma Issues Driving the Need
for Drug
Delivery
Declining Pharmaceutical Industry
Productivity
Patent Expirations and Declining Branded
Drug Sales
Pharmas Use Patent Extension Strategies
Many Pharmas Will Seek Partners for Drug
Delivery
New Crop of Drugs Will Reach the Market in
Near
Term
Limited Pharma Resources: Its Difficult to
Invent
New Drugs
Every Drug Needs a Drug Delivery System
Key Motivators for Developing Drug Delivery
Systems
Business Considerations
Genomics, Proteomics and Targeted
Therapies
Protein and Peptide Drugs
Expanding Knowledge About Disease
Mechanisms
Commercial and Technical Challenges of Drug
Delivery
Companies
Market is Diverse and Dynamic
An Expanding Industry
Companies Migrating to Become Specialty or
Generic
Pharmas
Business Trends
A Market Snapshot
The Pharma Industry Wants Drug Delivery
Systems
Changing Business Models
2.Drug Delivery Technology Developments
Delivery by Controlled Release Approaches
Oral Drug Delivery
New Formulations and Packaging
Chewable Tablets
Orally Disintegrating Tablets (ODTs)
Orally Disintegrating Film Strips (ODFs)
Enhancing Drug Bioavailability or
Solubility
Injection Drug Delivery
Needle-free Injection
Drug Delivery by Implantable Infusion Pump
Intraosseous Injection
Drug Delivery to Specific Organs
Lung Drug Delivery
Drug Delivery via the Nose
Delivery to the Cardiovascular System
Delivery to the Gastrointestinal Tract
Delivery to the Urogenital Tract
Drug Delivery into the Eye
Drug Delivery by Transdermal Methods
Drug Delivery to Mucosal Membranes
Targeting Selected Disease Sites
Drug Delivery by Polymers and Proteins
Drug Delivery by Small Particles
Monoclonal Antibodies
Drug Delivery by
Liposomes
Drug Delivery by
Heat-Activated Liposomes
Drug Delivery by
Microparticles
Drug Delivery by Modified Blood Cells
Drug Delivery by Nanoparticles
Viral Vectors for Gene Delivery
Non-Viral Vectors for Gene Delivery
3.Survey of Changing DDS Developments
Inhalation System
Polymer Development
Protein Drug Delivery
Therapeutic MAbs
Developments in Polyethylene Glycol (PEG)
Vaccines
Nanotech
Buccal Development
Drug Delivery to the Eye
Analyst Opinion: Next Generation Companies
4.Recent Strategic Alliances and M&As
Alliance Analysis: Deals Through 2006
Summaries of Drug Delivery Alliance Deals
5.Drug Delivery Systems Market Forecast
The US Drug Delivery Market
A Large Market
New Innovations Help Drugs Work Better
Demand for Less Invasive Drugs and
Treatments
Pharmaceutical Firms Can Differentiate
Products
The US Drug Delivery Market, 2005-2010E
Market Segments Defined by Route of
Administration
Oral Delivery Segment
Injectable Delivery Segment
Injection Devices Delivery Segment
Inhaled Delivery Segment
Inhaler Devices Segment
Transdermal Delivery Segment
Implant Delivery Segment
Transmucosal Delivery Segment
Therapeutic Antibodies Segment
Therapeutic & Cancer Vaccine Segment
Targeted Therapy/Delivery Segment
Other Delivery Segment
Market Shares of the US Drug Delivery
Market, 2005
and 2010
Market Map: DDS Companies by Technology
Categories
6.Patent Litigation Examples
University of Alabama v. Nektar Therapeutics
IVAX, Teva Pharmaceutical Industries Ltd.,
et al v.
Eli Lilly
Johnson & Johnson v. Boston Scientific
Chiron Corporation v. Corus Pharma, Inc.
Novartis Pharmaceuticals Corp., et al v. Sun
Pharmaceutical Industries Ltd.
GlaxoSmithKline Plc v. Par Pharmaceutical
Companies,
Inc. (Kali Laboratories, Inc.)
Santarus, Inc. v. TAP Pharmaceutical
Products, Inc.
Travanti Pharma Inc. v. IOMED
7.Drug Delivery With Nanotechnology
Nanotechnology
Companies Using Nanotechnology for Drug
Delivery
Commercializing Nanotechnology
Selected Nanotech R&D Companies
Activities of Selected Drug
Delivery Companies
Abgenix, Inc. (Amgen)
Alkermes, Inc.
Alnylam Pharmaceuticals, Inc.
Antigenics, Inc.
Aradigm Corporation
Cima Laboratories (Cephalon)
Elan Corporation
Intradigm Corporation
Medarex, Inc.
NanoBio Corporation
NanoMed Pharmaceuticals, Inc.
Nastech Pharmaceutical Company, Inc.
Nektar Therapeutics
Nexmed, Inc.
Noven Pharmaceuticals, Inc.
Palatin Technologies, Inc.
Raven Biotechnologies, Inc.
Sanofi Pasteur SA (Vaccines)
Sirna Therapeutics, Inc.
Skyepharma PLC
Sontra Medical Corporation
Watson Pharmaceuticals, Inc.
Wyeth
8.Appendices
Appendix A: Top Drug Delivery Companies
Appendix B: Drug Delivery Industry Websites
Pharmaceutical Industry Sites
Government Office Sites
Industry News Sites
Appendix C: Glossary of Terms
About the Publisher and Authors
About Takeda Pacific
About the Authors
List of Tables
Table 1. Drug Delivery Systems Market in US,
2005-2010
Table 2. Survey Results: Emerging Drug Delivery
Technologies
Table 3. Previous Survey Results: Top New DDS
Technologies
(2004)
Table 4. DDS Technology Review
Table 5. Strategic Alliance and M&A Analysis,
2004 through
Mid-2006
Table 6. Alliances in 2006
Table 7. Alliances in 2005
Table 8. Alliances in 2004
Table 9. Drug Delivery Market in the US by
Segments, 2005-
2010E
Table 10. US DDS Market Revenues by Share, 2005
and 2010E
Table 11. Competing DDS Companies by Technology
Categories
Table 12. Examples of Drug Delivery Litigations
Table 13. Drug Delivery Companies Using
Nanotechnology
Table 14. The Top Drug Delivery Companies by
Total Revenues
(2005)
List of Illustrations
Figure 1. Drug Delivery Systems Market in the
US, 2005-2010
Figure 2. Controlled Release Drug Delivery
System
Figure 3. The Oral Drug Delivery Route
Figure 4. Products Featuring Orally
Disintegrating Film
Strips
Figure 5. Injection Drug Delivery by Needle
Size
Figure 6. Implantable Insulin Delivery System
Figure 7. Inserting a Needle for Bone Marrow
Infusion
Figure 8. Airway Delivery by
Nektar
Figure 9. Close-up of Drug Delivery Mechanism
to the Lung
Figure 10. Two Leading Drug-Coated
Stents
Figure 11. Urogenital Drug Delivery For Men
Figure 12. Drug Delivery Mechanism for a
Transdermal Patch
Figure 13. The DOT Matrix Patch by
Noven
Figure 14. Drug Delivery Market in the US by
Segments, 2005-
2010E
Figure 15. US DDS Market Revenues by Share,
2005 and 2010E
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